DNA-protein cross-links as a biomarker of Cr(VI) exposure.
نویسندگان
چکیده
Comment on A. Zhitkovich et al. :Utilization of DNA-protein cross-links as a biomarker of chromium exposure. Environ Health Perspect 106(suppl 4):969-974 (1998).
منابع مشابه
DNA-protein cross-links in erythrocytes of freshwater fish exposed to hexavalent chromium or divalent nickel.
DNA-protein cross-links (DPXs) in fish erythrocytes represent a potential biomarker for exposure to metal cations, such as hexavalent chromium (Cr[VI]) and divalent nickel (Ni[II]). Species-specific sensitivities to DPX formation were studied by coexposure of juvenile specimens of rainbow trout, hybrid bluegill, and channel catfish to waterborne metals, such as Cr(VI) and Ni(II). In a species c...
متن کاملUtilization of DNA-protein cross-links as a biomarker of chromium exposure.
Human exposure to carcinogenic Cr(VI) compounds is found among workers in a large number of professional groups, and it can also occur through environmental pollution. A significant number of toxic waste sites contain Cr as a major contaminant. In this paper we summarize our efforts to apply measurements of DNA-protein cross-links (DPC) as test for biologically active doses of Cr(VI). DPC were ...
متن کاملMeasurement of DNA-protein cross-links in human leukocytes following acute ingestion of chromium in drinking water.
Increased DNA-protein cross-linking (DPX) in circulating leukocytes has been proposed as a potential biomarker for exposure and genotoxic damage caused by inhalation of certain reactive chemicals, such as hexavalent chromium [Cr(VI)]. This study was designed to determine whether ingestion of a single dose of potassium dichromate alone [Cr(VI)] or potassium dichromate fully reduced to Cr(III) wi...
متن کاملMonitoring human lymphocytic DNA-protein cross-links as biomarkers of biologically active doses of chromate.
A simple and sensitive assay for DNA-protein cross-links has been used as a biomarker of chromate exposure and early carcinogenic effects. Pilot studies of DNA-protein cross-links in peripheral blood lymphocytes have been conducted with individuals who had higher exposure to chromate, including welders, and with individuals who had lower levels of exposure such as residents living in a chromium...
متن کاملReductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI).
Induction of DNA damage by carcinogenic hexavalent chromium compounds [Cr(VI)] results from its reduction to lower oxidation states. Reductive metabolism of Cr(VI) generates intermediate Cr(V/IV)species, organic radicals, and finally Cr(III), which forms stable complexes with many biological ligands, including DNA. To determine the biological significance of different reaction products, we exam...
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 107 شماره
صفحات -
تاریخ انتشار 1999